Publications

Research articles (excerpt)

Schwartz C, Schmidt V, Deinzer A, Hawerkamp HC, Hams E, Bayerlein J, Röger O, Bailer M, Krautz C, El Gendy A, Elshafei M, Heneghan HM, Hogan AE, O'Shea D, Fallon PG. Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity. Sci Transl Med. 2022 Mar 9;14(635):eabj6879. doi: 10.1126/scitranslmed.abj6879

Saunders SP, Floudas A, Moran T, Byrne CM, Rooney MD, Fahy CMR, Geoghegan JA, Iwakura Y, Fallon PG, Schwartz C. Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation. Allergy. 2020 Dec; 75(12): 3216-3227. doi: 10.1111/all.14488

Schwartz C, Moran T, Saunders SP, Kaszlikowska A, Floudas A, Bom J, Nunez G, Iwakura Y, O’Neill LAJ, Irvine AD, McKenzie ANJ, Ogg G, Walsh PT, Demengeot J, Fallon PG. Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β. Allergy. 2019 Oct;74(10):1920-1933. doi: 10.1111/all.13801

Floudas A, Aviello G, Schwartz C, Jeffery IB, O'Toole PW, Fallon PG. Schistosoma Mansoni Worm Infection Regulates the Intestinal Microbiota and Susceptibility to Colitis. Infect Immun. 2019 Jul 23;87(8):e00275-19. doi: 10.1128/iai.00275-19

Schwartz C, Khan AR, Floudas A, Saunders SP, Hams E, Rodewald HR, McKenzie AN, Fallon PG. ILC2 regulate adaptive Th2 functions via PD-L1 checkpoint control. J Exp Med. 2017 Sept 4; 214(9):2507-2521. doi: 10.1084/jem.20170051

Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Amagai M, Ogg GS, McKenzie AN, Walsh PT, Fallon PG. Interleukin-17 receptor A maintains and protects the skin barrier to prevent allergic skin inflammation. J Immunol. 2017 Jul 15; 199(2):707-717. doi: 10.4049/jimmunol.1602185

Schwartz C, Eberle JU, Hoyler T, Diefenbach A, Lechmann M, Voehringer D. Opposing functions of TSLP-responsive basophils and dendritic cells in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2016 Nov; 138(5):1443-46. doi: 10.1016/j.jaci.2016.04.031

Schwartz C, Willebrand R, Huber S, Rupec RA, Wu D, Locksley R, Voehringer D. Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis. Blood. 2015 Jun 18;125(25):3896-904. doi: 10.1182/blood-2014-10-607788

Oeser K, Schwartz C, Voehringer D. Conditional IL-4/IL-13-deficient mice reveal a critical role of innate immune cells for protective immunity against gastrointestinal helminths. Mucosal Immunol. 2015 May; 8(3):672-82. doi: 10.1038/mi.2014.101

Schwartz C, Turqueti-Neves A, Hartmann S, Yu P, Nimmerjahn F, Voehringer D. Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion. Proc Natl Acad Sci U S A. 2014 Dec 2; 111(48):E5169-77. doi: 10.1073/pnas.1412663111/-/DCSupplemental

Schwartz C, Oeser K, Prazeres da Costa C, Layland L, Voehringer D. T cell-derived IL-4/IL-13 protects mice against fatal Schistosoma mansoni infection independently of basophils. J Immunol. 2014 Oct 1; 193(7):3590-9. doi: 10.4049/jimmunol.1401155

Hams E, Armstrong ME, Barlow JL, Saunders SP, Schwartz C, Cooke G, Fahy RJ, Crotty TB, Hirani N, Voehringer D, McKenzie AN, Donnelly SC, Fallon PG. IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proc Natl Acad Sci USA. 2014 Jan 7; 111(1):367-72. doi: 10.1073/pnas.1315854111

Ohnmacht C*, Schwartz C*, Panzer M, Schiedewitz I, Naumann R, Voehringer D. Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity. 2010 Sep 24; 33(3):364-74. (*equal contribution) doi: 10.1016/j.immuni.2010.08.011

Review articles

Schmidt V, Hogan AE, Fallon PG, Schwartz C. Obesity-Mediated Immune Modulation: One Step Forward,(Th) 2 Steps Back. Front Immunol. 2022 13:932893. doi: 10.3389/fimmu.2022.932893

Hawerkamp HC, Fahy CMR, Fallon PG, Schwartz C. Break on through: The role of innate immunity and barrier defence in atopic dermatitis and psoriasis. Ski Health Dis. 2022 2:e99. doi: 10.1002/ski2.99

Schwartz C, Fallon PG. Schistosoma “Eggs-Iting” the Host: Granuloma Formation and Egg Excretion. Front Immunol. 2018 Oct 29; 9: 2492. doi: 10.3389/fimmu.2018.02492

Schwartz C, Hams E, Fallon PG. Helminth Modulation of Lung Inflammation. Trends Parasitol. 2018 Jan 12. pii: S1471-4922(17)30312-4. doi: 10.1016/j.pt.2017.12.007

Schwartz C, O’Grady K, Lavelle EC, Fallon PG. Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity – emerging roles in obesity, intestinal inflammation, and cancer. Eur J Immunol. 2016 May; 46(5):1091-100. doi: 10.1002/eji.201545780

Schwartz C, Eberle JU, Voehringer D. Basophils in inflammation. Eur J Pharmacol. 2016 May 5; 778:90-5. doi: 10.1016/j.ejphar.2015.04.049


Other contributions

Fallon PG, Schwartz C. The high and lows of type 2 asthma and mouse models. J Allergy Clin Immunol. 2020 Feb;145(2):496-498. doi:

Schwartz C and Fallon PG. Determining Coreceptor Expression and Function in Murine ILC2 Through Flow Cytometry Characterization and Coculture Techniques. Methods Mol Biol. 2020;2121:71-82.

Schwartz C, Voehringer D. Identification of murine basophils by flow cytometry and histology. Methods Mol Biol. 2020; 2163:367-375.